If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

For two hundred years, Americans have believed that they have an obligation to improve the lot of humanity, a belief that has consistently shaped U.S. foreign policy. Yet within this consensus, there are two competing schools of thought: the "exemplarist" school (Brands' term) which holds that what America chiefly owes the world is the benign example of a well-functioning democracy, and the "vindicationist" school which argues that force must sometimes supplement a good example. In this book, H.W. Brands traces the (...) evolution of these two schools as they emerged in the thinking and writing of the most important public thinkers of the past two centuries. (shrink)

David Hume was one of the most important British philosophers of the eighteenth century. The first part of his Treatise on Human Nature is a seminal work in philosophy. Hume on Knowledge introduces and assesses: * Humes life and the background of the Treatise * The ideas and text in the Treatise * Humes continuing importance to philosophy.

Originally published in 1965 and written by one of the world's leading experts in animal behaviour, this book was written just as the impact of DNA on biology, genetics ethology and biophysics was being felt. The book reviews these developments and analyses the affect they have on our view of our own nature and of ethical and moral sense. It is particularly concerned with the impact of DNA and genetics on philosophic thought.

L'A. soutient, contre Germain Grisez, Joseph Boyle, John Finnis et William May, que le contrôle naturel des naissances pratiqué avec une intention mauvaise n'est pas contraception. Il montre que les auteurs identifient de façon incorrecte la fin prochaine de la contraception comme choix qu'il n'y ait pas d'enfant, alors que la fin prochaine véritable est d'empêcher un enfant de venir au monde . Ainsi donc, puisque en NFP un couple ne cherche pas à empêcher la venue au monde d'un enfant, (...) NFP n'implique pas d'action contraceptive. L'A. soutient aussi qu'identifier la fin prochaine comme choix qu'il n'y ait pas d'enfant ne spécifie pas de façon adéquate une classe homogène d'actes objectifs, bien que cela spécifie une classe homogène d'actes moraux. (shrink)

One area of language research that has received a great deal of attention, both theoretical and empirical, is the use of anaphoric expressions. Such expressions can be thought of as serving two functions: the primary function is to refer back to a referent from previous discourse, and the secondary, but no less important, function is to help provide discourse coherence and structure. Third person pronouns such as he or she are anaphoric expressions par excellence, but fuller anaphoric expressions, including demonstrative (...) and definite noun phrases (NPs) such as that woman and the woman are also used in natural discourse. In this chapter we shall focus primarily on issues concerning definite NP anaphor resolution, and in particular we shall examine the interaction of two factors that are related to the identification of antecedents: the focus status of the antecedent and the semantic relationship between the antecedent and the anaphor (including semantic overlap). After presenting these factors, we will discuss one particular approach to anaphor resolution, Almor's (1999) Informational Load Hypothesis (ILH), and present three experiments that examined the findings presented in Almor (1999). The results of these experiments will lead us to consider in more detail the secondary, discourse-structuring function of anaphoric expressions. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and (...) made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)